Frequently Asked Questions for JAKAFI® (ruxolitinib) and JAKAFI XR™ (ruxolitinib)
Healthcare Professionals
Enroll a PatientAbout IncyteCARES
What is IncyteCARES?
IncyteCARES is a program to help your eligible patients start and stay on therapy with an Incyte medicine by assisting with access and as-needed support.
How does IncyteCARES support Healthcare Professionals and their patients?
IncyteCARES offers an array of services and programs to Healthcare Professionals and their patients prescribed Incyte medications, which may include:
- Benefits verification for JAKAFI® (ruxolitinib) or JAKAFI XR™ (ruxolitinib)
- Prescription drug coverage guidance for patients
- Information about savings and financial support options, such as the:
- IncyteCARES Savings Program, which allows eligible patients with commercial prescription drug coverage to pay as little as $0 per month for their JAKAFI or JAKAFI XR, subject to certain limits
- Patient Assistance Program, which provides free medication for eligible patients who do not have prescription drug insurance or have trouble affording their out-of-pocket costs for JAKAFI or JAKAFI XR. No purchase contingencies or other obligations apply
- Temporary supply of JAKAFI or JAKAFI XR during coverage delays
- Delivery coordination of JAKAFI or JAKAFI XR from a specialty pharmacy to your office or directly to the patient’s home
- Education and support resources
- Information about organizations or independent foundations that may be able to assist with treatment-related costs, counseling, support groups, and more
ICD-10-CM codes for JAKAFI and JAKAFI XR- Sample Letter of Medical Necessity, Letter of Appeal, and Medical Exception templates for your use to help address insurer coverage denials
How can I enroll a patient in IncyteCARES?
You can enroll your patient by completing an IncyteCARES enrollment form, which can also serve as your patient’s prescription. You can download and fax the IncyteCARES Program Enrollment Form PDF or complete our online enrollment via our secure website. Note that not all patients who are prescribed JAKAFI or JAKAFI XR are eligible for enrollment or for all services we provide. Contact us at 1-855-452-5234 for more information.
Can a patient enroll themselves in IncyteCARES or must a provider initiate enrollment?
A patient can call IncyteCARES themselves to start the enrollment process. In that case, an IncyteCARES team member will reach out to the provider to get some of the information necessary for completing enrollment.
Can any patient who is prescribed JAKAFI or JAKAFI XR be enrolled in IncyteCARES?
Yes, any patient who has been prescribed JAKAFI or JAKAFI XR can enroll in IncyteCARES but may not be eligible to receive some of the services or support we offer. Contact IncyteCARES at 1-855-452-5234, Monday through Friday, 8 AM–8 PM ET for more information.
Does my patient need to sign the IncyteCARES Program Enrollment Form?
If you are requesting only a benefits investigation for JAKAFI or JAKAFI XR, your patient’s signature on the enrollment form is not necessary. If you are enrolling your eligible patient in IncyteCARES for our other services to support their treatment with JAKAFI or JAKAFI XR, the patient’s or the patient’s legal guardian’s authorization is required. If neither is available to sign an enrollment form with you, you can submit it without the signature and IncyteCARES will call the patient or legal guardian to request a verbal authorization.
Can I enroll a patient in IncyteCARES while waiting for insurance approval?
Yes, you can enroll a patient in IncyteCARES while waiting for insurance approval. In fact, once your patient is enrolled, the IncyteCARES team can assist with benefits verification or provide support in the event that coverage is denied. Additionally, if insurance approval is delayed, we may be able to provide your enrolled patient with a free, short-term supply of JAKAFI or JAKAFI XR.
How can I contact IncyteCARES?
Call us at 1-855-452-5234. Our IncyteCARES team is available Monday through Friday, 8 AM–8 PM ET.
Benefits Investigation
Can IncyteCARES assist with benefits verification for my patent’s JAKAFI or JAKAFI XR?
Yes, IncyteCARES can assist with benefits verification for enrolled patients. We can contact the insurer to get information about the patient’s coverage, out-of-pocket costs, and any special requirements, such as specific specialty pharmacies or prior authorization. We will provide this information to both you and your patient.
How long does it take for IncyteCARES to complete my patient’s benefits investigation?
We can complete most benefit verifications within 3 business days. If we encounter a delay, we will notify you and your patient within that time period.
What is the appeal process if a patient’s insurer denies coverage for their medication?
If a patient’s insurer denies coverage, IncyteCARES will provide information to Healthcare Professionals and patients about filing an appeal. Our team will monitor the appeal process and facilitate communication with the insurance company. If the appeal is delayed or unsuccessful, IncyteCARES will assess the patient’s eligibility to receive the medication free of charge.
If I prescribe JAKAFI XR for my patient and the insurance company denies coverage, what can IncyteCARES do to help?
When you prescribe JAKAFI XR and enroll your patient in IncyteCARES, we can do a benefit verification for both JAKAFI XR and JAKAFI. If coverage for JAKAFI XR is denied, IncyteCARES will contact you to discuss whether JAKAFI is covered for the patient.
If you decide to prescribe JAKAFI instead, our IncyteCARES representative will send you the JAKAFI enrollment form to complete. If, at a later time, you would like to change the prescription to JAKAFI XR, an IncyteCARES representative can assist you with that.
Can IncyteCARES help if a patient’s insurance changes during treatment?
If a patient’s insurance changes during treatment, they should call IncyteCARES at 1-855-452-5234. We can determine any changes in their coverage or their out-of-pocket costs. We can also find out if the specialty pharmacy they had been using is still within network for the new insurer and can communicate any changes to the pharmacy or help change to a new pharmacy if needed.
Filling the Prescription
How do patients fill their prescription for JAKAFI or JAKAFI XR?
JAKAFI and JAKAFI XR are dispensed by specialty pharmacies that are part of our Incyte-designated network. We can coordinate prescription fills and delivery to enrolled patients. We can also contact the patient’s insurer to confirm that the pharmacy is approved under the patient’s insurance plan.
Which specialty pharmacies dispense JAKAFI and JAKAFI XR?
A list of specialty pharmacies in our network and their contact information can be found by downloading the following PDF: Specialty Pharmacies List (PDF)
Can I contact the specialty pharmacies directly to order JAKAFI or JAKAFI XR?
Yes, you can send prescriptions directly to an in-network specialty pharmacy; however, your patients may be better served by being enrolled in IncyteCARES. We can assist enrolled patients by coordinating delivery of their medication, identifying savings and financial assistance options for which they may be eligible, and more. The IncyteCARES Program Enrollment Form can also serve as your patient’s first prescription.
Savings Program
Does IncyteCARES offer a copay assistance program for JAKAFI or JAKAFI XR?
Yes, IncyteCARES offers a Savings Program for eligible patients with commercial prescription insurance. Patients enrolled in the Savings Program can receive their medication for as little as $0 per month, subject to certain limits.*
*Uninsured, cash-paying, or Alternate Funding Program (AFP) patients are not eligible. Not valid for patients insured through Medicare Part D, Medicare Advantage, Medicaid, TRICARE, or any state medical or pharmaceutical assistance program. Patient enrollment in a copay adjustment program, such as a maximizer or accumulator program, may impact the value of this offer. Annual benefit maximum applies, as may other restrictions. Valid prescription for JAKAFI® (ruxolitinib) or JAKAFI XR™ (ruxolitinib) extended-release tablets for an FDA-approved indication or compendia-recognized use is required. Please see the full Patient Terms and Conditions or call IncyteCARES at 1-855-452-5234. Update effective as of April 1, 2026.
What are the eligibility criteria for the Savings Program?
To qualify, patients must:
- Have commercial prescription drug coverage. Patients insured under federal or state government prescription drug programs—including Medicare Part B or D, Medicare Advantage, Medicaid, or TRICARE—are not eligible. Patients without prescription drug coverage are also not eligible
- Be a resident of the United States or Puerto Rico
- Have a valid prescription for JAKAFI or JAKAFI XR for an FDA-approved use
Under the IncyteCARES Savings Program, how much do eligible patients pay for JAKAFI or JAKAFI XR?
Enrolled patients pay as little as $0 per month for their prescription, subject to certain limits. See the complete terms and conditions.
How can I enroll an eligible patient in the IncyteCARES Savings Program?
When your patient is enrolled in IncyteCARES, our team immediately enrolls that patient in the Savings Program if they are eligible. Another option is to enroll an eligible patient for the Savings Program yourself at IncyteCARESsavings.JAKAFI.com. Either way, a program member number is immediately issued and can be used right away. We will also mail your patient a welcome letter. Your patient does not need to be enrolled in IncyteCARES to access the Savings Program.
Once a patient is approved for the IncyteCARES Savings Program, do they ever have to reenroll?
No. The patient’s enrollment in the Savings Program will automatically renew each year. However, they should contact IncyteCARES if their prescription insurance changes, so we can update their information and confirm that they are still covered.
Patient Assistance Program
Are patients who have Medicare or government coverage eligible for copay or financial assistance with IncyteCARES?
Patients who have Medicare Part D may be eligible to receive JAKAFI or JAKAFI XR free of charge through the IncyteCARES Patient Assistance Program as long as they meet household income requirements and other criteria.* This program helps eligible patients who are uninsured or underinsured and need help affording the out-of-pocket cost for their medication. Call IncyteCARES at 1-855-452-5234, Monday through Friday, 8 AM–8 PM ET to find out more.
*Terms and conditions apply. Terms of this program may change at any time.
What are the eligibility criteria for this free medication program?*
To qualify for the Patient Assistance Program (PAP), patients must:
- Be confirmed as eligible for and enrolled in IncyteCARES
- Be a resident of the United States or Puerto Rico
- Have a valid prescription for JAKAFI or JAKAFI XR for an FDA-approved use
- Meet one of these 3 criteria:
Uninsured
- Have no prescription drug coverage and meet household income criteria
Underinsured†
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- Have Medicare Part B, Medicare Part D, or Medicare Advantage and meet household income criteria
- Have any other type of prescription drug insurance (commercial, Medicaid, etc) but have exhausted or been denied coverage for JAKAFI or JAKAFI XR and meet household income criteria
*Free medication is offered without any purchase contingency or other obligation. Terms and conditions apply. Terms of this program may change at any time.
†Patients who are enrolled in an Alternate Funding Program (AFP) are not eligible to receive free drug.
How long does it take to find out if a patient has been approved for the PAP?
Once we receive the completed enrollment form, we can provide conditional approval within 3 business days. If we encounter a delay, we will notify you and your patient within that time period.
How does conditional approval work for the PAP?
We provide conditional approval for the program, lasting up to 90 days, based on the patient’s enrollment form information. During this period, the patient must provide their income documentation to IncyteCARES before they can receive full approval for the PAP.
What are acceptable documents to validate income for the PAP?
Acceptable documents for supporting current household income include the patient’s most current tax return, W-2 earnings statements, or one month of recent pay stubs.
Temporary Patient Assistance Program
Which patients qualify for the Temporary Patient Assistance Program?
Eligible patients with commercial prescription drug coverage who are experiencing a delay in coverage for their JAKAFI or JAKAFI XR (prescribed for an FDA-approved indication) may qualify for a free short-term supply. Proof of claim submission is required. No purchase contingencies or other obligations apply.
How can I enroll a patient in the Temporary Patient Assistance Program?
Your patient must first be enrolled in IncyteCARES. In addition, you or your patient must also submit proof of the claim submission/coverage delay, such as a letter from the insurer. Our team at IncyteCARES is available to provide support to assist with this process.
How long can a patient receive free medication while waiting for approval?
Eligible patients may be able to receive a free 30-day supply of medicine. Free product is offered to eligible patients without any purchase contingency or other obligation.
Education and Support
What sort of education does IncyteCARES provide?
Through our call center, we can answer questions about JAKAFI and JAKAFI XR and basic questions about the patient’s condition. We make it clear that we don’t provide medical advice and that the information we provide does not replace any provided by their Healthcare Professionals. For some indications, we also offer additional educational resources including disease education brochures and videos to help support patients during treatment with JAKAFI or JAKAFI XR. Every patient enrolled in IncyteCARES receives a condition-specific Welcome Kit with complete program details.
If I am prescribing JAKAFI XR for a patient currently taking JAKAFI, what is the recommended way for the patient to make that transition?
Please speak with Incyte Medical Information or your Incyte sales representative concerning how a patient should transition from JAKAFI to JAKAFI XR. You can reach Incyte Medical Information at
What travel/transportation support is available through IncyteCARES?
IncyteCARES itself does not offer this kind of support; however, we share information about certain nonprofit organizations that may be able to assist with medical-related travel or transportation expenses. Patient eligibility would be determined by the organization.
What information does IncyteCARES offer for patients who need social, emotional, and other types of support?
We can connect patients to nonprofit organizations that provide social and emotional support as well as information about other counseling services and support groups in their areas. Please contact us for current information about these support services.
